Figure 6.

hNSCs improved nerve fibers in APP/PS1 mice brains. (A) Microtubule associated protein 2 (MAP2)-staining sections in the brains of PBS, NSC group and WT mice, and quantification of MAP2-staining in the frontal cortex and hippocampus of three groups of mice. There was no significant difference in % area of neuropil between the NSC group and WT mice (ns. = p > 0.05), *p < 0.05; **p < 0.01 vs. the PBS group. Scale bar: 20 μm. (B) Ultrastructure analysis showed the enlargement and disorganization of unmyelinated nerves in the cortex and hippocampus of PBS group mice; the damage was alleviated in NSC group. Likewise, myelinated nerves maintained relatively intact in myelin sheath in NSC group and WT mice. Arrow indicates the nerve fibers. Scale bar: 1 μm.