Table 1.
PD patient demographics according to cognitive impairment group (MCI).
| Demographic data | PD non-MCI | PD with MCI | Difference p-value | PD all |
|---|---|---|---|---|
| TIME 1 | ||||
| N | 12 | 12 | N/A | 27 |
| Age | 58.2±5.4 | 62.25±5.6 | 0.941 | 60.3±5.5 |
| Male/Female | 6/6 | 8/4 | 0.248 | 15/12 |
| Years since diagnosis | 3.8±3.4 | 5.0±3.1 | 0.343 | 4.4±3.3 |
| Education | 14.6±2.5 | 13.8±3.2 | 0.495 | 14.1±3.0 |
| Hand R/L/A | 7/4/1 | 10/0/2 | 0.063 | 19/4/4 |
| MoCA (off medication) | 28.4±1.6 | 27.3±1.0 | 0.02 | 27.9±1.8 |
| UPDRS (off medication) | 27.2±8.9 | 26.9±8.3 | 0.935 | 26.6±8.1 |
| BDI | 6.0±4.2 | 11.3±6.1 | 0.046 | 9.0±5.7 |
| TIME 2 | ||||
| Age | 59.9±5.5 | 64.0±5.5 | 0.083 | 61.9±5.5 |
| Years since diagnosis | 5.3±3.6 | 6.4±3 | 0.417 | 6.1±3.4 |
| MoCA (off medication) | 29.1±1.2 | 27±1.3 | 0.001 | 28±1.6 |
| UPDRS (off medication) | 27.3±6 | 26.9±8.3 | 0.918 | 26.6±7.5 |
| BDI | 7.8±3.9 | 11.3±6.1 | 0.119 | 9.3±5.4 |
The p-values indicate the group difference based on chi-squared test (sex and handedness) or student t-test (others). Legend: MoCA, Montreal cognitive assessment; UPDRS, Unified Parkinson's disease Rating Scale; BDI, Beck Depressive Inventory II. Individual MoCA scores are presented in Supplementary Table 3.