Table 3.
Significant activations in the contrasts for RNF minus RPF, and MNF minus MPF.
| Anatomical Area | Non-MCI | MCI | Non-MCI and MCI (conjunction) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Time 1 | Time 2 | Time 1 | Time 2 | Time 1 | Time 2 | ||||||||
| XYZ | t | XYZ | t | XYZ | t | XYZ | t | XYZ | t | XYZ | t | ||
| RNF–RPF | |||||||||||||
| DLPFC | L | −40, 38, 8 | 3.95* | ||||||||||
| R | 40, 28, 18 | 4.49* | 42, 24, 18 | 4.46* | |||||||||
| 44, 34, 14 | 4.34* | ||||||||||||
| VLPFC | L | −32, 26, 0 | 5.01 | ||||||||||
| R | 32, 24, 2 | 4.82 | 30, 26, −6 | 4.71* | 32, 28, −2 | 4.36* | 20, 28, −4 | 7.92 | |||||
| mPFC | L | −6, 28, 40 | 4.19* | −8, 26, 40 | 4.29* | −16, 26, 42 | 8.38 | ||||||
| R | 6, 24, 36 | 4.12* | |||||||||||
| pPFC | L | −42, 6, 32 | 4.69* | −40, 12, 24 | 4.64* | −42, 10, 28 | 4.52* | −38, 10, 26 | 4.98 | −40, 10, 30 | 7.35 | ||
| R | 44, 8, 20 | 4,37* | 38, 6, 24 | 5.11 | 44, 8, 24 | 4.28* | 44, 14, 30 | 4.8* | 40, 14, 24 | 6.07 | 44, 10, 28 | 8.34 | |
| 40, 14, 24 | 4.26* | 38, 18, 22 | 4.45* | ||||||||||
| Parietal | L | −30, −70, 28 | 5.77 | −32, −60, 38 | 4.67* | ||||||||
| R | 32, −74, 20 | 5.38 | 32, −60, 50 | 4.17 | 30, −70, 32 | 5.34 | |||||||
| 26, −64, 56 | 3.99* | ||||||||||||
| Precuneus | L | −10, −74, 48 | 4.29* | ||||||||||
| Occipital | L | −22, −82, −14 | 6.98 | −24, −78, −8 | 4.34* | ||||||||
| −40, −84, 14 | 4.5* | ||||||||||||
| R | 40, −82, 6 | 4.11* | 36, −84, 12 | 5.35 | 42, −80, 12 | 4.01* | 40, −84, 12 | 5.28 | 40, −82, 12 | 5.33 | 38, −84, 12 | 9.71 | |
| 30, −60, −12 | 6.73 | 20, −66, 26 | 4.58* | 26, −60, −12 | 7.39 | ||||||||
| Cerebellum | L | −10, −80, −28 | 4.99 | ||||||||||
| −32, −66, −32 | 4.62* | ||||||||||||
| R | 8, −80, −26 | 4.42* | |||||||||||
| 30, −70, −30 | 4.31* | ||||||||||||
| Caudate | L | −14, 20, −4 | 3.77** | ||||||||||
| R | 16, 16, −6 | 3.48** | |||||||||||
| MNF−MPF | |||||||||||||
| DLPFC | L | −46, 40, 28 | 5.23 | −46, 30, 34 | 5.01 | ||||||||
| R | 42, 40, 32 | 4.74* | 42, 30, 36 | 4.54* | |||||||||
| 46, 40, 22 | 5.2 | ||||||||||||
| PMC | L | −26, 30, 58 | 4.08* | ||||||||||
| R | 24, 24, 58 | 4.78* | |||||||||||
| VLPFC | L | −32, 26, −8 | 4.64* | ||||||||||
| R | 32, 26, −8 | 4.04* | |||||||||||
| mPFC | L | −2, 16, 50 | 3.95* | ||||||||||
| R | 0, 28, 44 | 5.63 | 6, 24, 44 | 4.62* | |||||||||
| aPFC | L | −36, 54, 12 | 5.02 | −32, 52, 8 | 4.4* | −32, 52, 8 | 6.33 | ||||||
| R | 38, 56, 18 | 4.5* | 32, 60, 6 | 4.15* | |||||||||
| 38, 50, 6 | 4.21* | ||||||||||||
| 42, 52, 14 | 4.03* | ||||||||||||
| Parietal | L | −34, −54, 40 | 4.84* | −34, −62, 38 | 5.44 | −30, −54, 44 | 4.33* | −32, −56, 40 | 6.01 | ||||
| −62, −66, 30 | 4.24* | ||||||||||||
| R | 36, −62, 60 | 4.69* | 22, −70, 60 | 4.23* | |||||||||
| 50, −44, 54 | 4.35* | 46, −62, 52 | 4.1* | ||||||||||
| Precuneus | L | −4, −76, 48 | 4.33* | −12, −74, 56 | 4.82* | −4, −78, 50 | 5.98 | ||||||
| R | 2, −68, 44 | 4.48* | 14, −78, 56 | 4.31* | |||||||||
| Occipital | L | −26, −96, 0 | 5.5 | −30, −84, −12 | 4.05* | ||||||||
| R | 34, −92, 0 | 5.75 | −28, −84, 34 | 5.06 | 28, −80, −18 | 4.13* | |||||||
| 32, −74, 24 | 4.13* | ||||||||||||
| Cerebellum | L | −40, −76, −46 | 4.37* | −32, −76, −16 | 4.46* | ||||||||
| −6, −78, −26 | 4.29* | ||||||||||||
| −18, −84, −22 | 4.1* | ||||||||||||
| R | 24, −86, −20 | 4.74* | 30, −64, −32 | 4.76* | |||||||||
Legend. Results presented at t > 4.82; p < 0.05 corrected for multiple comparisons.
*
predicted regions (t > 3.87; p < 0.0001).
**
trends (t > 3.18; p < 0.001). t, t-value; L, left; R, right; DLPFC, dorsolateral prefrontal cortex (BA 46, 9/46); pPFC, posterior PFC (BA 6, 8, 44); VLPFC, ventrolateral prefrontal cortex and insula (BA 47/12/13); aPFC, anterior prefrontal cortex (BA 10); mPFC, medial prefrontal cortex (BA 6, 8, 32); Parietal, parietal cortex (BA 40, 7); Precuneus, precuneus cortex (BA 40, 7); Occipital, occipital or striate/ extrastriate cortices (BA 17, 18, 19); PMC, premotor area (BA 6).