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. 2016 Nov 23;7:526. doi: 10.3389/fimmu.2016.00526

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Copyright © 2016 Oliveira, Macedo, Collares, Freitas, Donate, Sakamoto-Hojo, Donadi and Passos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Posttranscriptional miRNA–mRNA interaction network based on microarray expression data. The network of control mTEC cells (A) shows the participation of six miRNAs of let-7 family that interact with PTA mRNAs targets. The highlighted interaction (let-7a–Hmga2 mRNA) was selected for further validations. The network of Aire-knockdown mTEC cells (B) shows the participation of 15 miRNAs from different families that interact with a restricted group of PTA mRNA targets. The highlighted interaction (miR-378–Prpsap1 mRNA) was selected for further validations. Interaction networks were reconstructed by using the GenMir⁺⁺ algorithm, which consider the respective modulation of miRNAs (upregulated) and of mRNA targets (downregulated).