Figure 4.
Effects of MDPV (1 mg·kg−1, s.c.) on BP (A and B) and HR (C and D) alone and after pretreatment with the α‐adrenoceptor antagonist prazosin (Praz 0.3 mg·kg−1, s.c.) or the β‐adrenoceptor antagonist propranolol (Prop 1.0 mg·kg−1, s.c.). A and C show actual results for each individual treatment. Dark bars are treatments that are significantly different (P<0.05) from the saline + saline control (Sal + Sal). * P<0.05, significant differences between pretreatment + MDPV compared with MDPV alone. B and D show change scores whereby effects of saline, prazosin + saline or propanolol + saline are subtracted from the effects of the corresponding MDPV treated group. Dark bars are significantly different (P<0.05) from MDPV 1 – Saline. Each bar is mean ± SEM (n = 7) for the first hour of the session.