Figure 2.
Effects of nicotine alone and in combination with 1 mg·kg−1 of mecamylamine or 3.2 mg·kg−1 of DHβE in monkeys discriminating nicotine (1.78 mg·kg−1) while receiving 8.9 mg·kg−1·day−1 of nicotine. Abscissae: saline (Sal) or dose of nicotine in mg·kg−1 body weight administered s.c. Ordinates: mean (± SEM) percentage of responding on the nicotine lever (top) and mean (± SEM) rate of responding expressed as a percentage of control (bottom). The data for nicotine alone in the corresponding left and right panels are identical. Data are the means of five monkeys per group.