Figure 3.
Effects of nicotine (left), epibatidine (middle) and RTI‐36 (right) in monkeys discriminating nicotine (1.78 mg·kg−1) without additional nicotine treatment (i.e. Intermittent) or while receiving 8.9 mg·kg−1·day−1 of nicotine (i.e. Daily). Abscissae: saline (Sal) or dose in mg·kg−1 body weight administered s.c. Ordinates: mean (± SEM) percentage of responding on the nicotine lever (top) and mean (± SEM) rate of responding expressed as a percentage of control (bottom). The nicotine data for the Daily group are re‐plotted from Figure 1. Data for nicotine and RTI‐36 are the means of five monkeys per group. Data for epibatidine are the means of four monkeys per group, except for the dose of 0.0178 mg·kg−1 in the Daily group, which are from two monkeys.