Figure 5.

Effects of nicotine alone and in combination with 3.2 mg·kg⁻¹ of varenicline (left) or 32 mg·kg⁻¹ of cytisine (right) in monkeys discriminating nicotine (1.78 mg·kg⁻¹) while receiving 8.9 mg·kg⁻¹·day⁻¹ of nicotine. Abscissae: saline (Sal) or dose of nicotine in mg·kg⁻¹ body weight administered s.c. Ordinates: mean (± SEM) percentage of responding on the nicotine lever (top) and mean (± SEM) rate of responding expressed as a percentage of control (bottom). The effects of varenicline (3.2 mg·kg⁻¹) and cytisine (32 mg·kg⁻¹) alone are shown above Sal and are re‐plotted from Figure 4. Data for nicotine alone are re‐plotted from Figure 1. Data are the means of five monkeys per group.