Table 1.

Published binding affinities and efficacies of nAChR ligands at α4β2 and α7 nAChRs

Drug	K i (nM) α4β2	K i (nM) α7	Ratio α4β2/α7	% ACh at α4β2	% ACh at α7
Nicotine	3.5a	244a	70	40d	43d
(+/−)‐Epibatidine	0.026b	198b	7615	131d	150d
RTI‐36	0.037b	>1000b	>1000	ND	ND
Varenicline	0.91c	37c	41	13d	74d
Cytisine	2.1c	228c	109	9c	83c

^aGrady et al. (2010).

^bCarroll et al. (2005).

^cSala et al. (2013).

^dOndachi et al. (2015).

ND, not determined.