Table 2.
Statistical comparison of slopes and intercepts of dose–effect functions for nicotine alone versus nicotine in combination with another test drug for discriminative stimulus effects and corresponding ED50 values in the Daily nicotine treatment group
| Test drug (dose mg·kg−1) | Slope | Intercept | ED50 (mg·kg−1) |
|---|---|---|---|
| Nicotine alone | – | – | 0.67 |
| + Mecamylamine (1) | F 1,22 = 0.60, P = 0.45 | F 1,24 = 41.4, P < 0.05a | 3.7 |
| + DHβE (3.2) | F 1,20 = 0.11, P = 0.74 | F 1,22 = 2.08 P = 016 | 0.92 |
| + Varenicline (3.2) | F 1,20 = 2.49, P = 0.13 | F 1,22 = 6.75, P < 0.05a | 0.31 |
| + Cytisine (32) | F 1,16 = 1.09, P = 0.31 | F 1,18 = 14.5, P < 0.05a | 0.19 |
The F‐ratio values compare the slope and intercept of the control nicotine dose–effect function (i.e. Nicotine alone) to the respective slope and intercept of the nicotine dose–effect function determined in the presence of another test drug.
a
Significant difference in potency versus nicotine alone.