Table 3.
Statistical comparison of slopes and intercepts of the dose–effect functions for each test drug in the Intermittent versus Daily nicotine treatment groups for discriminative stimulus effects and corresponding ED50 values
| Test drug | Slope | Intercept | ED50 (mg·kg−1) | |
|---|---|---|---|---|
| Intermittent | Daily | |||
| Nicotine | F 1,20 = 2.65, P = 0.12 | F 1,22 = 2.70, P = 0.11 | 0.40 | 0.67 |
| Epibatidine | F 1,11 = 0.06, P = 0.82 | F 1,13 = 0.01, P = 0.92 | 0.0075 | 0.0078 |
| RTI‐36 | F 1,21 = 0.0013, P = 0.97 | F 1,23 = 0.21, P = 0.65 | 0.027 | 0.037 |
| Varenicline | N/A | N/A | 0.72 | N/Aa |
| Cytisine | F 1,16 = 1.97, P = 0.18 | F 1,18 = 1.05, P = 0.32 | 34 | 48 |
F‐ratio values compare the slopes and intercepts of the dose–effect functions for each drug determined in the absence of daily nicotine treatment (i.e. Intermittent) versus the presence of daily nicotine treatment (i.e. Daily).
a
Significant difference Intermittent versus Daily.
N/A, not applicable; % nicotine‐lever responding was not increased to greater than 50% in the Daily nicotine treatment group.