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. 2016 Nov 1;173(24):3480–3491. doi: 10.1111/bph.13639

Figure 7.

Figure 7

Kv7 blocker XE991 antagonizes the vasorelaxant effects of fasudil on precontracted rat mesenteric artery segments. (A) Representative tension trace of the effect of ACh (1 μM) on a mesenteric artery segment precontracted with phenylephrine (Phe; 10 μM). (B) Representative tension trace of the effect of fasudil (0.1–100 μM) on a mesenteric artery segment precontracted with Phe (10 μM). (C) Representative tension trace of the effect of fasudil (0.1–300 μM) + XE991 (10 μM) on a mesenteric artery segment precontracted with Phe (10 μM). (D) Representative tension trace of the effect of fasudil (0.1–300 μM) on a mesenteric artery segment precontracted with KCl (60 mM). (E) Concentration‐response relationships for fasudil. Data are fitted with the logistic equation. The EC50s are 0.83 ± 0.25 μM (fasudil/Phe, n = 13) and 5.04 ± 0.96 μM (fasudil + XE991/Phe, n = 11) and 5.73 ± 0.26 μM (fasudil/KCl, n = 7).