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. 2016 Nov 18;7:13384. doi: 10.1038/ncomms13384

Figure 7. Synthesis of PCO371.

Figure 7

Reagents and conditions: (a) 4-trifluoromethoxybenzoic acid, HATU, DIPEA and DMF, room temperature; (b) 30% H2O2 aq., 2 mol l−1 NaOH aq., EtOH, room temperature, then 5 mol l−1 NaOH aq., 50 °C; (c) 4 mol l−1 HCl in dioxane, CH2Cl2, room temperature; (d) 2-chloroethane-1-sulfonyl chloride, Et3N, CH2Cl2, room temperature. (e) 1-(4-bromo-3,5-dimethylphenyl)-5,5-dimethylimidazolidine-2,4-dione, Pd(dba)2, t-Bu3P-HBF4, methyl dicyclohexylamine, NMP, 100 °C; (f) 20% Pd(OH)2/C, H2, DMF–MeOH–MeCN, room temperature.