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. 2016 Nov 18;7:13384. doi: 10.1038/ncomms13384

Figure 8. Synthesis of compound 9.

Figure 8

Reagents and conditions: (g) 2-bromoisobutyric acid, DIPEA, DMI, 100 °C; (h) 5 mol l−1 NaOH aq., MeOH, 75 °C; (i) NaOCN, AcOH, CH2Cl2, room temperature.