Table 3.
Reaction rate constants for biochemical kinetics used in the simulation.
| Extrinsic pathway | Intrinsic pathway | Perforin pathway | |||||
|---|---|---|---|---|---|---|---|
| k 11 | 0.5 μM−1s−1 | k 21 | 0.5 μM−1s−1 | k 28 + | 1 μM−1s−1 | k 41 † | 0.5 μM−1s−1 |
| k 12 + | 1 μM−1s−1 | k 22 | 0.5 μM−1s−1 | k 28 − | 1 s−1 | k 42 + † | 1 μM−1s−1 |
| k 12 − | 1 s−1 | k 23 + | 1 μM−1s−1 | k 29 | 10 μM−1s−1 | k 42 − † | 1 s−1 |
| k 13 | 1 s−1 | k 23 − | 1 s−1 | k 30 + | 1 μM−1s−1 | k 43 † | 1 s−1 |
| k 14 + | 1 μM−1s−1 | k 24 | 1 s−1 | k 30 − | 1 s−1 | k 44 + † | 1 μM−1s−1 |
| k 14 − | 1 s−1 | k 25 + | 1 μM−1s−1 | k 31 | 1 s−1 | k 44 − † | 1 s−1 |
| k 15 | 1 s−1 | k 25 − | 1 s−1 | k 32 + | 10 μM−1s−1 | k 45 † | 1 s−1 |
| k 16 | 1 μM−1s−1 | k 26 | 1 s−1 | k 32 − | 0.5 s−1 | k 46 † | 1 μM−1s−1 |
| k 51 + † | 1 μM−1s−1 | k 27 + | 1 μM−1s−1 | k 33 | 0.1 s−1 | k 53 + † | 1 μM−1s−1 |
| k 51 − † | 1 s−1 | k 27 − | 1 s−1 | k 34 | 1 μM−1s−1 | k 53 − † | 1 s−1 |
| k 52 † | 1 s−1 | k 55 + † | 1 μM−1s−1 | k 56 † | 1 s−1 | k 54 † | 1 s−1 |
| k 55 − † | 1 s−1 | ||||||
†, estimated parameters. All other values are taken from [24]. The superscript “+” indicates forward rate constant and “−” reverse rate constant. The units for reaction rate constants are μM−1s−1 for bimolecular reactions and s−1 for monomolecular reactions.