Table 5.

Parameter values used in the extracellular components of the model.

Symbol	Parameter	Value	Ref.
D u	Nutrient (oxygen) diffusion coefficient	0.00197 mm2/s	[32]
γ u	Single cell oxygen consumption rate	2.69 × 10−17 M/cells/s	[33]
δ u	Nutrient (oxygen) decay rate	0∗	Est.
ϵ	Degree of localized nutrient consumption	0.1	Est.
D m	MDE diffusion coefficient	10−7 mm2/s	[34]
μ	Single cell MDE production rate	1∗	[19]
δ m	MDE decay rate	0∗	[19]
δ f	ECM degradation rate	50∗	[19]
D w	Inhibitor (lactate) diffusion coefficient	1.67 × 10−6 mm2/s	[16]
α	Inhibitory factor production rate	2%/h/cm3	[16]
T 1, T 2	Nutrient threshold for necrosis and quiescent states	0.3, 0.4∗	Est.
T 3	Growth inhibitor threshold	20∗	Est.

∗: nondimensionalized value.