Table 1.

Comparison of predicted disorder scores between PTM sites and non-PTM sites. Predicted disorder score rages from 0 to 1. Higher score mean larger possibility of being in a disordered region. The p-value for the significance of the disorder score difference is based on two-tailed, two-sample student t-test.

PTM	UniProt keyword	# of PTM sites	Amino acid	Mean fluctuation (Å)			p-value
				PTM sites		Non-PTM sites
Phosphorylation	Phosphoserine	53080	S	0.81	>	0.59	0
Phosphorylation	Phosphothreonine	13477	T	0.69	>	0.49	0
Phosphorylation	Phosphotyrosine	8075	Y	0.46	>	0.35	7.58E-287
Phosphorylation	Phosphohistidine	357	H	0.40	<	0.47	2.28E-14
Phosphorylation	4-aspartylphosphate	529	D	0.20	<	0.51	1.74E-240
Methylation	Cysteine methyl ester	491	C	0.78	>	0.35	6.82E-199
Methylation	N6-methyllysine	499	K	0.78	>	0.56	2.22E-64
Methylation	Glutamate methyl ester	40	E	0.84	>	0.58	8.63E-21
Methylation	Omega-N-methylarginine	98	R	0.81	>	0.52	1.01E-20
Methylation	Leucine methyl ester	14	L	0.69	>	0.41	5.59E-11
Methylation	N5-methylglutamine	10	Q	0.57	>	0.55	9.22E-02
Methylation	Pros-methylhistidine	10	H	0.37	<	0.47	1.07E-01
Methylation	N4-methylasparagine	65	N	0.46	<	0.49	6.14E-02
Methylation	5-methylarginine	11	R	0.46	<	0.53	5.30E-02
Methylation	S-methylcysteine	12	C	0.26	<	0.35	3.14E-02
Methylation	Tele-methylhistidine	47	H	0.12	<	0.47	7.77E-167
Dimethylation	Asymmetric dimethylarginine	385	R	0.90	>	0.52	3.67E-171
Dimethylation	Symmetric dimethylarginine	57	R	0.91	>	0.52	3.76E-25
Dimethylation	N6,N6-dimethyllysine	340	K	0.72	>	0.56	8.13E-25
Dimethylation	Omega-N-methylated arginine	247	R	0.72	>	0.52	1.04E-18
Trimethylation	N6-methylated lysine	374	K	0.69	>	0.56	1.36E-18
Trimethylation	N6,N6,N6-trimethyllysine	696	K	0.57	>	0.56	1.92E-01
Hydroxylation	4-hydroxyproline	900	P	0.89	>	0.60	2.27E-236
Hydroxylation	5-hydroxylysine	179	K	0.97	>	0.56	8.65E-136
Hydroxylation	3-hydroxyproline	11	P	1.00	>	0.60	6.28E-128
Acetylation	N2-acetylarginine	32	R	0.67	>	0.52	3.09E-05
Acetylation	N6-acetyllysine	11436	K	0.54	<	0.56	6.83E-09
ADP-ribosylation	ADP-ribosylcysteine	12	C	0.30	<	0.35	3.79E-01
ADP-ribosylation	ADP-ribosylasparagine	8	N	0.15	<	0.49	1.71E-06
ADP-ribosylation	ADP-ribosylserine	7	S	0.46	<	0.59	4.80E-10
ADP-ribosylation	ADP-ribosylarginine	87	R	0.18	<	0.52	3.26E-78
Deamidation	Deamidated glutamine	43	Q	0.77	>	0.55	4.86E-20
Deamidation	Deamidated asparagine	74	N	0.42	<	0.49	3.80E-02
FAD attachment	Pros-8alpha-FAD histidine	21	H	0.54	>	0.47	4.39E-02
FAD attachment	Tele-8alpha-FAD histidine	36	H	0.33	<	0.47	2.04E-11
FAD attachment	S-8alpha-FAD cysteine	52	C	0.21	<	0.35	2.40E-23
FMN conjugation	FMN phosphoryl threonine	33	T	0.37	<	0.49	3.01E-10
FMN conjugation	S-4a-FMN cysteine	21	C	0.20	<	0.35	6.46E-13
Carboxylation	4-carboxyglutamate	647	E	0.65	>	0.58	1.66E-19
Geranyl-geranylation	S-geranylgeranyl cysteine	29	C	0.81	>	0.35	3.20E-12
Palmitoylation	S-palmitoyl cysteine	155	C	0.29	<	0.35	1.03E-02
S-diacylglycerol cysteine	S-diacylglycerol cysteine	37	C	0.39	>	0.35	2.36E-01
S-Nitrosylation	S-nitrosocysteine	56	C	0.27	<	0.35	8.63E-06
Sulfation	Sulfotyrosine	561	Y	0.58	>	0.35	2.87E-77
Dihydroxylation	4,5-dihydroxylysine	8	K	0.32	<	0.56	3.93E-05
Bromination	6′-bromotryptophan	24	W	0.46	>	0.30	1.21E-03
Beta-methylthiolation	3-methylthioaspartic acid	503	D	0.38	<	0.51	0