Table 4. The effects of pre-weaning (gestation and lactation) or post-weaning diets (canned or kibbled) on the Metabolism of cofactors and vitamins KEGG orthology pathway (proportion of total sequences) present in faecal samples of the domestic kitten (Felis catus; n = 5 per treatment).

KEGG Orthlology Level Three function	K-K		K-C		C-K		C-C		Pre-weaning diet1		Post-weaning diet2		Pre x Post-weaning
Metabolism of cofactors and vitamins	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM	P-value	FDR	P-value	FDR	P-value	FDR
Thiamine metabolism [PATH:ko00730]	0.51	0.08	1.31	0.15	0.55	0.13	1.20	0.12	0.786	0.968	0.001	0.006	0.541	0.650
Ubiquinone/other biosynthesis [PATH:ko00130]	0.09	0.03	0.35	0.05	0.14	0.05	0.28	0.05	0.813	0.968	0.001	0.006	0.204	0.586
Riboflavin metabolism [PATH:ko00740]	0.25	0.08	0.47	0.05	0.21	0.08	0.52	0.04	0.846	0.968	0.004	0.012	0.515	0.650
Folate biosynthesis [PATH:ko00790]	0.30	0.06	0.02	0.01	0.23	0.09	0.08	0.07	0.887	0.968	0.004	0.012	0.270	0.586
Biotin metabolism [PATH:ko00780]	0.06	0.02	0.16	0.05	0.06	0.03	0.14	0.04	0.742	0.968	0.017	0.041	0.817	0.817
Lipoic acid metabolism [PATH:ko00785]	0.10	0.03	0.02	0.01	0.04	0.02	0.04	0.01	0.252	0.968	0.054	0.108	0.074	0.586
One carbon pool by folate [PATH:ko00670]	0.49	0.10	0.69	0.12	0.67	0.08	0.80	0.08	0.163	0.968	0.110	0.172	0.722	0.788
Pantothenate/CoA biosynthesis [PATH:ko00770]	0.15	0.05	0.33	0.04	0.24	0.10	0.28	0.04	0.765	0.968	0.115	0.172	0.288	0.586
Vitamin B6 metabolism [PATH:ko00750]	0.21	0.05	0.32	0.03	0.31	0.05	0.32	0.06	0.382	0.968	0.216	0.275	0.324	0.586
Nicotinate/nicotinamide metabolism [PATH:ko00760]	0.77	0.18	0.43	0.10	0.70	0.23	0.61	0.14	0.763	0.968	0.229	0.275	0.470	0.650
Porphyrin/chlorophyll metabolism [PATH:ko00860]	0.20	0.08	0.20	0.06	0.05	0.02	0.49	0.36	0.974	0.974	0.257	0.280	0.236	0.586
Retinol metabolism [PATH:ko00830]	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.125	0.968	0.749	0.749	0.342	0.586

Results are presented as mean and standard error of the mean (SEM). P value indicates ANOVA significance of rank transformed data and False Discovery Rate (FDR) indicates multiple testing adjusted P value.

K = Kibbled.

C = Canned.

Diet K-Diet K (K-K) n = 3 females, n = 2 males.

Diet C-Diet K (C-K) n = 3 females, n = 2 males.

Diet K-Diet C (K-C) n = 3 females, n = 2 males.

Diet C-Diet C (C-C) n = 4 females, n = 1 male.

¹Comparisons between Diets K-K and K-C vs C-K and C-C.

²Comparison between Diets K-K and C-K and C-C and K-C.