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. 2016 Nov 23;6:34668. doi: 10.1038/srep34668

Table 5. The effects of pre-weaning (gestation and lactation) or post-weaning diets (canned or kibbled) on the enzymes involved in key vitamin biosynthesis and metabolism related pathways the Ubiquinone and other terpenoid-quinone biosynthesis [PATH:ko00130], Thiamine metabolism [PATH:ko00730], Sulfur relay system [PATH:ko04122], Riboflavin metabolism [PATH:ko00740], Vitamin B6 metabolism [PATH:ko00750], Nicotinate and nicotinamide metabolism [PATH:ko00760], Pantothenate and CoA biosynthesis [PATH:ko00770], Biotin metabolism [PATH:ko00780], and Folate biosynthesis [PATH:ko00790] KEGG orthology pathways (proportion of total sequences) present in faecal samples of the domestic kitten (Felis catus; n = 5 per treatment).

    K-K K-C C-K C-C Pre-weaning diet1 Post-weaning diet2 Pre x Post-weaning
  KEGG ID Mean SEM Mean SEM Mean SEM Mean SEM P-value FDR P-value FDR P-value FDR
Ubiquinone and other terpenoid-quinone biosynthesis [PATH:ko00130]
 Menb; [EC:4.1.3.36] K01661 0.003 0.001 0.136 0.033 0.055 0.029 0.168 0.036 0.143 0.321 0.003 0.008 0.726 0.838
 Menh; [EC:4.2.99.20] K08680 0.000 0.000 0.005 0.002 0.000 0.000 0.000 0.000 0.008 0.029 0.001 0.005 0.025 0.075
 Ubib, aarf K03688 0.086 0.035 0.008 0.008 0.046 0.046 0.033 0.027 0.820 0.914 0.214 0.269 0.267 0.466
 Ubif; [EC:1.14.13.-] K03184 0.000 0.000 0.012 0.005 0.000 0.000 0.000 0.000 0.001 0.007 0.001 0.005 0.001 0.005
 Ubih; [EC:1.14.13.-] K03185 0.000 0.000 0.009 0.003 0.001 0.000 0.000 0.000 0.001 0.007 0.001 0.005 0.001 0.005
Ubix; [EC:4.1.1.-] K03186 0.000 0.000 0.007 0.004 0.000 0.000 0.000 0.000 0.009 0.032 0.048 0.076 0.041 0.111
 Mend; [EC:2.2.1.9] K02551 0.000 0.000 0.075 0.029 0.000 0.000 0.057 0.036 0.639 0.810 0.017 0.033 0.670 0.802
 Menf; [EC:5.4.4.2] K02552 0.000 0.000 0.009 0.004 0.000 0.000 0.001 0.001 0.003 0.013 0.001 0.005 0.007 0.024
 Mena; [EC:2.5.1.74/EC:2.5.1.-] K02548 0.000 0.000 0.000 0.000 0.033 0.012 0.000 0.000 0.003 0.013 0.002 0.006 0.003 0.012
Ubia; [EC:2.5.1.-] K03179 0.000 0.000 0.008 0.004 0.001 0.001 0.000 0.000 0.027 0.083 0.068 0.100 0.012 0.039
 Ubic; [EC:4.1.3.40] K03181 0.000 0.000 0.007 0.002 0.000 0.000 0.000 0.000 0.001 0.007 0.001 0.005 0.001 0.005
 Ubie; [EC:2.1.1.163/EC:2.1.1.201] K03183 0.000 0.000 0.023 0.010 0.004 0.002 0.016 0.016 0.891 0.955 0.097 0.134 0.591 0.753
 Entc; [EC:5.4.4.2] K02361 0.025 0.015 0.011 0.007 0.000 0.000 0.000 0.000 0.019 0.061 0.322 0.378 0.342 0.538
 Ubig; [EC:2.1.1.222/EC:2.1.1.64] K00568 0.000 0.000 0.005 0.002 0.000 0.000 0.000 0.000 0.001 0.007 0.008 0.018 0.003 0.012
 Ubid; [EC:4.1.1.-] K03182 0.001 0.001 0.024 0.013 0.000 0.000 0.000 0.000 0.007 0.025 0.034 0.057 0.029 0.084
Thiamine metabolism [PATH:ko00730]
 Thil; [EC:2.7.4.16] K01516 0.090 0.037 0.144 0.051 0.093 0.036 0.191 0.025 0.529 0.730 0.063 0.094 0.569 0.742
 Thi80; [ec:2.7.6.2] K00949 0.036 0.015 0.000 0.000 0.010 0.010 0.007 0.007 0.317 0.532 0.043 0.069 0.105 0.239
 Tena; [EC:3.5.99.2] K03707 0.001 0.000 0.003 0.003 0.034 0.015 0.009 0.009 0.052 0.145 0.241 0.296 0.112 0.250
 Thig K03149 0.135 0.076 0.327 0.051 0.197 0.056 0.264 0.043 0.994 0.996 0.049 0.077 0.303 0.501
 Thih K03150 0.105 0.096 0.703 0.106 0.117 0.080 0.530 0.056 0.367 0.573 0.001 0.005 0.307 0.503
 Thik; [EC:2.7.1.89] K07251 0.000 0.000 0.004 0.001 0.000 0.000 0.000 0.000 0.001 0.007 0.001 0.005 0.001 0.005
 Sufs; [EC:2.8.1.7/EC:4.4.1.16] K11717 0.142 0.058 0.128 0.059 0.029 0.029 0.164 0.068 0.539 0.737 0.297 0.354 0.181 0.360
Sulfur relay system [PATH:ko04122]
 Thif; [EC:2.7.7.73] K03148 0.012 0.012 0.004 0.004 0.031 0.017 0.014 0.014 0.269 0.493 0.354 0.411 0.652 0.788
 Thii K03151 0.101 0.041 0.007 0.007 0.041 0.029 0.022 0.022 0.374 0.579 0.049 0.077 0.229 0.420
 This K03154 0.003 0.003 0.000 0.000 0.009 0.004 0.004 0.004 0.155 0.341 0.216 0.271 0.740 0.848
Riboflavin metabolism [PATH:ko00740]
 Fre, ubib; [EC:1.16.1.3/EC:1.5.1.41] K05368 0.000 0.000 0.009 0.003 0.000 0.000 0.000 0.000 0.001 0.007 0.001 0.005 0.001 0.005
 Ribb, RIB3; [EC:4.1.99.12] K02858 0.085 0.030 0.265 0.024 0.099 0.069 0.307 0.041 0.559 0.751 0.002 0.006 0.745 0.851
 Ribd; [EC:3.5.4.26/EC:1.1.1.193] K11752 0.070 0.029 0.000 0.000 0.025 0.015 0.020 0.020 0.501 0.705 0.058 0.088 0.100 0.232
 Ribe, RIB5; [EC:2.5.1.9] K00793 0.042 0.017 0.065 0.029 0.000 0.000 0.073 0.020 0.427 0.631 0.034 0.057 0.194 0.377
 Ribh, RIB4; [EC:2.5.1.78] K00794 0.050 0.010 0.115 0.011 0.041 0.023 0.124 0.019 0.977 0.986 0.001 0.005 0.607 0.761
 Ssue; [EC:1.5.1.38] K00299 0.000 0.000 0.004 0.001 0.000 0.000 0.000 0.000 0.001 0.007 0.002 0.006 0.002 0.008
 Apha; [EC:3.1.3.2] K03788 0.000 0.000 0.008 0.003 0.000 0.000 0.000 0.000 0.006 0.022 0.002 0.006 0.002 0.008
 Epd; [EC:1.2.1.72] K03472 0.000 0.000 0.013 0.005 0.000 0.000 0.000 0.000 0.004 0.017 0.001 0.005 0.002 0.008
 Pdxs, pdx1; [EC:4.-.-.-] K06215 0.210 0.054 0.207 0.029 0.252 0.060 0.157 0.025 0.922 0.968 0.261 0.317 0.297 0.496
 Pdxj; [EC:2.6.99.2] K03474 0.000 0.000 0.055 0.010 0.001 0.001 0.066 0.018 0.569 0.759 0.001 0.005 0.601 0.758
Nicotinate and nicotinamide metabolism [PATH:ko00760]
 Iunh; [EC:3.2.2.1] K01239 0.000 0.000 0.002 0.002 0.118 0.052 0.017 0.017 0.007 0.025 0.107 0.145 0.087 0.208
 Nada; [EC:2.5.1.72] K03517 0.065 0.027 0.077 0.052 0.000 0.000 0.117 0.059 0.773 0.885 0.145 0.190 0.224 0.417
 Nadc, QPRT; [EC:2.4.2.19] K00767 0.066 0.027 0.175 0.027 0.000 0.000 0.190 0.026 0.283 0.509 0.001 0.005 0.087 0.208
 Nadd; [EC:2.7.7.18] K00969 0.074 0.036 0.000 0.000 0.030 0.018 0.009 0.009 0.438 0.643 0.015 0.030 0.224 0.417
 Pncb, NAPRT1; [EC:2.4.2.11] K00763 0.165 0.067 0.000 0.000 0.150 0.065 0.027 0.027 0.901 0.960 0.013 0.026 0.640 0.788
 Pnta; [EC:1.6.1.2] K00324 0.023 0.013 0.016 0.003 0.060 0.021 0.003 0.002 0.342 0.553 0.016 0.031 0.052 0.136
 Pntb; [EC:1.6.1.2] K00325 0.037 0.022 0.013 0.003 0.089 0.017 0.007 0.002 0.137 0.311 0.004 0.010 0.054 0.140
 Ppnk, NADK;[EC:2.7.1.23] K00858 0.060 0.025 0.014 0.014 0.064 0.039 0.012 0.012 0.982 0.988 0.071 0.103 0.928 0.968
 Puna; [EC:2.4.2.1] K03783 0.061 0.025 0.083 0.038 0.000 0.000 0.126 0.033 0.723 0.858 0.019 0.036 0.070 0.174
 Stha, udha; [EC:1.6.1.1] K00322 0.000 0.000 0.014 0.005 0.000 0.000 0.000 0.000 0.002 0.010 0.002 0.006 0.001 0.005
 Yjjg; [EC:3.1.3.5] K08723 0.000 0.000 0.007 0.003 0.000 0.000 0.000 0.000 0.001 0.007 0.001 0.005 0.001 0.005
 5’-nucleotidase; [EC:3.1.3.5] K01081 0.001 0.000 0.007 0.007 0.008 0.005 0.000 0.000 0.811 0.908 0.767 0.807 0.220 0.411
 Nade; [EC:6.3.1.5] K01916 0.152 0.014 0.000 0.000 0.068 0.037 0.000 0.000 0.054 0.150 0.001 0.005 0.048 0.128
 Pnca; [EC:3.5.1.19 3.5.1.-] K08281 0.011 0.007 0.000 0.000 0.062 0.029 0.000 0.000 0.086 0.222 0.001 0.005 0.075 0.184
 Usha; [EC:3.1.3.5 3.6.1.45] K11751 0.000 0.000 0.013 0.007 0.000 0.000 0.000 0.000 0.017 0.055 0.039 0.063 0.013 0.042
Pantothenate and CoA biosynthesis [PATH:ko00770]
 Acps; [EC:2.7.8.7] K00997 0.027 0.011 0.003 0.003 0.024 0.015 0.008 0.008 0.863 0.939 0.063 0.094 0.662 0.795
 Pand; [EC:4.1.1.11] K01579 0.000 0.000 0.062 0.006 0.010 0.008 0.057 0.012 0.704 0.852 0.001 0.005 0.370 0.569
 Pane, apba; [EC:1.1.1.169] K00077 0.080 0.023 0.016 0.005 0.026 0.019 0.016 0.011 0.100 0.245 0.043 0.069 0.125 0.275
 Coaa; [EC:2.7.1.33] K00867 0.045 0.018 0.014 0.006 0.057 0.030 0.000 0.000 0.958 0.982 0.031 0.054 0.464 0.654
 Coaw; [EC:2.7.1.33] K09680 0.000 0.000 0.009 0.004 0.000 0.000 0.002 0.002 0.115 0.270 0.019 0.036 0.088 0.209
 Panb; [EC:2.1.2.11] K00606 0.000 0.000 0.080 0.020 0.004 0.004 0.085 0.025 0.751 0.876 0.001 0.005 0.989 0.995
 Panc; [EC:6.3.2.1] K01918 0.000 0.000 0.114 0.005 0.000 0.000 0.068 0.028 0.158 0.344 0.001 0.005 0.160 0.326
 Acph; [EC:3.1.4.14] K08682 0.000 0.000 0.006 0.002 0.000 0.000 0.000 0.000 0.002 0.010 0.004 0.010 0.003 0.012
Biotin metabolism [PATH:ko00780]
 Biod; [EC:6.3.3.3] K01935 0.000 0.000 0.025 0.011 0.000 0.000 0.008 0.008 0.332 0.544 0.031 0.054 0.346 0.542
 Bira; [EC:6.3.4.15] K03524 0.059 0.024 0.000 0.000 0.018 0.018 0.014 0.014 0.323 0.537 0.051 0.079 0.118 0.262
 Biof; [EC:2.3.1.47] K00652 0.002 0.001 0.112 0.032 0.041 0.033 0.093 0.038 0.689 0.842 0.019 0.036 0.307 0.503
Folate biosynthesis [PATH:ko00790]
 Folc; [EC:6.3.2.12 6.3.2.17] K11754 0.147 0.060 0.000 0.000 0.060 0.037 0.023 0.023 0.418 0.622 0.023 0.042 0.174 0.348
 Folp; [EC:2.5.1.15] K00796 0.054 0.022 0.000 0.000 0.020 0.017 0.010 0.010 0.410 0.613 0.045 0.072 0.144 0.302
 Paba; [EC:2.6.1.85] K01664 0.029 0.017 0.008 0.004 0.043 0.016 0.009 0.007 0.526 0.727 0.037 0.061 0.592 0.753
 Pabc; [EC:4.1.3.38] K02619 0.000 0.000 0.003 0.003 0.034 0.017 0.009 0.009 0.038 0.111 0.275 0.331 0.198 0.382
 Suld; [EC:4.1.2.25/EC:2.7.6.3] K13940 0.038 0.024 0.000 0.000 0.070 0.024 0.008 0.008 0.287 0.511 0.020 0.037 0.474 0.660

Results are presented as mean and standard error of the mean (SEM). P value indicates ANOVA significance of rank transformed data and False Discovery Rate (FDR) indicates multiple testing adjusted P value.

K = Kibbled.

C = Canned.

Diet K-Diet K (K-K) n = 3 females, n = 2 males.

Diet C-Diet K (C-K) n = 3 females, n = 2 males.

Diet K-Diet C (K-C) n = 3 females, n = 2 males.

Diet C-Diet C (C-C) n = 4 females, n = 1 male.