Table 1. Main characteristics of all studies included in the meta-analysis.

First author & Ref. No.	Study Type	Country	Ethnicity	Control	Cases	Type	MBL2 gene variants/SNPs	Methods	Association
Wu et al.11	CC	China	Asian	453	151	PTB	P > Q, Y > X, H > L, A > B	PCR-RFLP	No
Chen et al.12	CC	China	Asian	419	503	TB	Y > X,	PCR-SSP	Yes
Chen et al.13	CC	China	Asian	216	205	TB	Y > X,	PCR-SSP	Yes
Garcia et al.14	CC	Spain	Caucasian	106	76	PTB, EPTB	A > O	PCR-SSP	No
Heidi et al.15	CC	Brazil	Mixed	148	155	PTB, EPTB	H > L, Y > X, A > O, A > D, A > B, A > C	Sequencing	A > O, A > C risk
Araujo et al.16	CC	Brazil	Mixed	159	167	PTB, EPTB	A > B, A > C, A > D, A > O	PCR	No
Singla et al.17	CC	India	Asian	392	357	PTB, EPTB	A > B	PCR-RFLP	Yes
Thye et al.18	CC	Ghana	African	2346	2230	PTB	H > L, Y > X, P > Q, A > C	Pyrosequencing	A > C
de Wit et al.19	CC	South Africa	African	318	505	TB	A>B, A > D, A > C	PCR-RFLP ARMS-PCR	No
Capparelli et al.20	CC	Italy	Caucasian	288	277	PTB	A > O	PCR	Protective
Cossar et al.21	CC	Turkey	Caucasian	44	99	PTB, EPTB	A > B	PCR-RFLP	Protective
Alagarasu et al.22	CC	India	Asian	146	366	HIV + PTB, EPTB	A > B, A > D, A > C, A > O, Y > X	PCR-SSP	Y > X, A > O
Soborg et al.23	CC	Tanzania	African	426	443	PTB	A > B, A > D, A > C, A > O	PCR-RFLP	No
Liu et al.24	CC	China	Asian	293	152	PTB	H > L, P > Q, Y > X, A > B	PCR-SSP	No
Garcia et al.25	CC	Spain	Caucasian	344	127	TB	A > O	PCR-RFLP PCR-SSP	No
Selvaraj et al.26	CC	India	Asian	58	48	PTB	A > O	PCR-SSOP	No
Fitness et al.27	CC	Malawi	African	546	322	HIV+−TB	A > C	F-PCR ARMS-PCR	Yes
Soborg et al.28	CC	Denmark	Mixed	250	109	TB	A > O, A > B, A > D, A > C	PCR-SSP	No
Ozbaş et al.29	CC	Turkey	Caucasian	100	49	PTB	A > B	PCR	No
Selvaraj et al.30	CC	India	Asian	109	202	PTB	A > B, A > C, A > D, A > O	PCR	A > C
Hoal et al.31	CC	South Africa	African	79	155	PTB, Meningeal TB	A > B, A > C, A > D	PCR-RFLP	Protective A > B
Bellamy et al.32	CC	Gambia	African	422	397	PTB	A > B, A > C	PCR	Protective A > C

Note: *MBL2 gene variants designated as: rs1800451 (A > C), rs1800450 (A > B), rs5030737 (A > D), rs7096206 (Y > X), rs11003125 (H > L), rs7095891 (P > Q), Combined rs1800450, rs1800451, rs5030737 (A > O).

**CC = Case-control study; TB = Tuberculosis; PTB = Pulmonary tuberculosis; EPTB = Extrapulmonary tuberculosis; HIV = Human immunodeficiency virus.