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. 2016 Nov 23;6:37623. doi: 10.1038/srep37623

Figure 6. TMA construction coupled with automated IHC analysis showing HZE particle radiation-associated alterations in activated Casp3, CK-5, ColIII, Decorin, Desmin, p63, and SULF2 in brain, kidney, liver, lung, and spleen tissues.

Figure 6

(A) Representative microphotographs of the TMA constructed with brain, kidney, liver, lung, and spleen tissues from mice exposed to mock-IR or HZE particle radiation, and subjected to automated IHC for Casp3, CK-5, ColIII, Decorin, Desmin, p63, and SULF2. (B) Representative photo-micrographs showing random regions (20X) of corresponding tissues exhibiting staining pattern, localization, and the positivity intensity of Casp3, CK-5, ColIII, Decorin, Desmin, p63, and SULF2 after HZE particle radiation compared with mock-IR. (C) Histograms obtained from Aperio TMA image quantification analysis showing HZE particle radiation-associated magnifications of Casp3, CK-5, ColIII, Decorin, Desmin, p63, and SULF2 in brain, kidney, liver, lung, and spleen tissues.