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. 2016 Nov 23;6:36904. doi: 10.1038/srep36904

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Differentially expressed miRNAs (adjusted p < 0.05) in severely diseased aortic valve tissue with Pearson correlation coefficient more than 50%. Different colours distinguish the different groups identified by the Markov clustering algorithm. Boxes list the top three KEGG pathways associated with the miRNAs in each cluster by DIANA miRPath. The dashed separator is used to separate up- and down-regulated miRNAs, but the network was analysed as a whole. Abbreviations: KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase; PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase; TGF, transforming growth factor.