Table 3. Pathway analysis incorporating mRNA profiles.
| KEGG pathway | Adjusted p-value | |
|---|---|---|
| A. Integrated miRNA/mRNA analysis | Focal adhesion | 0.0001 |
| Regulation of actin cytoskeleton | 0.002 | |
| ECM-receptor interaction | 0.002 | |
| Dorso-ventral axis formation | 0.003 | |
| PI3K-Akt signaling pathway | 0.003 | |
| Platelet activation | 0.008 | |
| Pathways in cancer | 0.015 | |
| ErbB signaling pathway | 0.045 | |
| Tight junction | 0.046 | |
| Leukocyte transendothelial migration | 0.047 | |
| B. mRNA analysis | Focal adhesion | 0.001 |
| Olfactory transduction | 0.006 | |
| PI3K-Akt signaling pathway | 0.034 |
Pathways were identified using ClueGO in Cytoscape for (A) integrated miRNA/mRNA results and (B) mRNA results only, using differentially expressed miRNAs and genes. Abbreviations: ECM, extracellular matrix; KEGG, Kyoto Encyclopedia of Genes and Genomes; PI3K, phosphatidylinositol-4, 5-bisphosphate 3-kinase.