Table 4. Prognostic analysis of individual SNPs for DMFS.
Covariate | No. of patients | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|
3y DMFS(%) | p-value | HR (95%CI) | p-value | ||
PI3KCA:rs6443264 | 0.069 | 0.151 | |||
TT | 68 | 92.0 | Reference | ||
TG or GG | 428 | 84.2 | 1.958 (0.782,4.905) | ||
PI3KCA:rs2699887 | 0.384 | 0.456 | |||
GG | 451 | 84.7 | Reference | ||
GA or AA | 40 | 89.7 | 0.680 (0.247,1.875) | ||
AKT1:rs1130214 | 0.029 | 0.075 | |||
GG | 369 | 86.9 | Reference | ||
GT or TT | 111 | 78.0 | 1.566 (0.956,2.567) | ||
AKT1:rs3803304 | 0.592 | 0.649 | |||
CC | 412 | 84.7 | Reference | ||
CG or GG | 84 | 86.8 | 0.861(0.452,1.640) | ||
AKT1:rs2494738 | 0.106 | 0.027 | |||
GG | 85 | 80.5 | Reference | ||
GA or AA | 377 | 86.9 | 0.530 (0.302,0.929) | ||
AKT1:rs2498804 | 0.208 | 0.221 | |||
TT | 203 | 87.6 | Reference | ||
TG or GG | 288 | 83.2 | 1.354 (0.833,2.200) | ||
AKT1:rs249732 | 0.162 | 0.124 | |||
CC | 257 | 87.6 | Reference | ||
CT or TT | 220 | 83.1 | 1.450 (0.903,2.328) | ||
AKT1:rs3803300 | 0.025 | 0.045 | |||
GG | 52 | 74.5 | Reference | . | |
GA or AA | 424 | 86.7 | 0.536 (0.292,0.986) | ||
AKT2:rs2304186 | 0.757 | 0.625 | |||
GG | 115 | 88.0 | Reference | ||
GT or TT | 373 | 84.6 | 1.151(0.656,2.020) | ||
AKT2:rs892119 | 0.219 | 0.075 | |||
GG | 356 | 84.1 | Reference | ||
GA/AA | 110 | 88.0 | 0.579 (0.317–1.057) | ||
mTOR:rs11121704 | 0.165 | 0.085 | |||
TT | 422 | 86.3 | Reference | ||
CT or CC | 74 | 79.5 | 1.655 (0.933,2.935) | ||
mTOR:rs2295080 | 0.949 | 0 | 0.739 | ||
TT | 307 | 85.6 | Reference | ||
GT or GG | 189 | 84.7 | 1.065 (0.665,1.707) | ||
PTEN:rs2299939 | 0.470 | 0.560 | |||
CC | 331 | 84.5 | Reference | ||
CA or AA | 163 | 86.7 | 0.862 (0.522,1.422) | ||
PTEN:rs11202607 | 0.460 | 0.569 | |||
CC | 385 | 84.4 | Reference | ||
CT or TT | 111 | 88.1 | 0.844 (0.471,1.512) | ||
PTEN:rs701848 | 0.660 | 0.488 | |||
TT | 162 | 84.7 | Reference | ||
TC or CC | 329 | 85.3 | 0.844 (0.523,1.363) | ||
PTEN:rs12569998 | 0.539 | 0.458 | |||
TT | 198 | 83.4 | Reference | ||
TG/GG | 297 | 86.5 | 0.840 (0.529–1.333) |