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. 2016 Nov 23;6:37580. doi: 10.1038/srep37580

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Panels show DAPI (a), PV+ cells (b), PNNs ((c); stained with WFA) from representative rats at PND90. Across both conditions the total number of DAPI labelled nuclei decreased steadily from infancy to early adulthood (main effect of Age, p < 0.0001). PV+ interneurons increased from PND7 to PND35 before declining at PND90 (main effect of Age, p < 0.0001). While PV+ cell density was reduced across development in polyI:C treated animals, this effect was not significant (main effect of Treatment, p = 0.07). The number of perineuronal nets increased throughout postnatal development (main effect of Age, p < 0.0001). Insets are representative images from each condition. Scale bar represents 250 μm. *p < 0.001.