Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Nov 23;6:37580. doi: 10.1038/srep37580

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Panels show DAPI (a), IBA1 (c) and GFAP (b). Across both conditions the total number of DAPI labelled nuclei decreased throughout postnatal development (main effect of Age, p < 0.0001). Microglial density was increased slightly throughout postnatal development aside from a dramatic spike in density in the PND21 cohort (main effect of Age, p < 0.001; Age × Treatment, p = 0.056). GFAP staining was sparsely present within the cortical parenchyma, instead clustering around the cortical surface and blood vessels throughout the tissue. GFAP staining intensity increased from PND21 to PND35 where it leveled off into maturity (main effect of Age, p < 0.0001). Neither polyI:C treated animals or controls showed significant differences between either of these immune markers. Insets are representative images from each condition. Scale bar represents 250 μm. *p < 0.05.