Figure 3. Association of CSF sTREM2 with the AD CSF core biomarkers.

• A–F
  Scatter plots representing association of CSF sTREM2 with T‐tau (A, B), P‐tau_181P (C, D), and Aβ_1–42 (E, F) in the control and AD continuum groups. Each point depicts the value of CSF sTREM2 of a subject, and the solid lines indicate the regression line for each of the groups calculated by a linear mixed‐effects model adjusted by age and gender (fixed effects) and center (random effects). The standardized regression coefficients (β) and the P‐values are also shown. The sample contained some extreme values of T‐tau and P‐tau_181P. We did not exclude any value, but we performed a bootstrapping for each association in order to ensure that the associations were not driven by these extreme values.