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. 2016 Nov 22;16:914. doi: 10.1186/s12885-016-2945-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Correlative analyses of MMP-2, MMP-9 and sIL-2Rα in the CSF. (a to d) Activated MMP-2 has a bias toward lower levels when compared to baseline during treatment with mTMZ. The mean MMP-2 level has a direct correlation with OS but not PFS. (e to h) The level of activated MMP-9 is highly variable during treatment with mTMZ, but there was no correlation with OS or PFS. (i to l) sIL-2Rα levels are also highly variable among individual patients. Baseline sIL-2Rα level has an inverse correlation with time from initial diagnosis to first recurrence. There is a trend for correlation between increased sIL-2Rα level and OS but not PFS