Table 1.

Matrix of structural diversity across clusters

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
1	.73	.64	.42	.25	.67	.39	.50	.31	.67	.42	.31	.41	.53	.34	.69	.39	.39	.33	.39	.58
2	.64	.76	.39	.27	.73	.42	.58	.39	.48	.47	.33	.24	.42	.47	.70	.70	.50	.27	.45	.70
3	.42	.39	.85	.52	.34	.38	.48	.67	.40	.36	.38	.41	.50	.32	.46	.33	.39	.57	.32	.33
4	.25	.27	.52	.77	.31	.53	.47	.75	.33	.31	.67	.26	.31	.26	.32	.24	.31	.63	.25	.33
5	.67	.73	.34	.31	.79	.38	.55	.38	.37	.42	.38	.37	.34	.45	.69	.61	.44	.45	.23	.77
6	.39	.42	.38	.53	.38	.71	.74	.53	.50	.33	.65	.22	.28	.34	.54	.45	.36	.47	.34	.37
7	.50	.58	.48	.47	.55	.74	.66	.53	.33	.39	.58	.26	.34	.45	.61	.58	.50	.47	.27	.57
8	.31	.39	.67	.75	.38	.53	.53	.80	.40	.31	.50	.30	.41	.37	.39	.27	.42	.63	.25	.37
9	.67	.48	.40	.33	.37	.50	.33	.40	.91	.72	.30	.33	.38	.39	.50	.55	.39	.37	.43	.63
10	.42	.47	.36	.31	.42	.33	.39	.31	.72	.91	.25	.50	.36	.42	.56	.42	.47	.33	.34	.28
11	.31	.33	.38	.67	.38	.65	.58	.50	.30	.25	.80	.20	.19	.29	.39	.33	.31	.47	.25	.33
12	.41	.24	.41	.26	.37	.22	.26	.30	.33	.50	.20	.98	.41	.35	.30	.30	.28	.22	.30	.30
13	.53	.42	.50	.31	.34	.28	.34	.41	.38	.36	.19	.41	.64	.29	.53	.45	.25	.31	.36	.38
14	.34	.47	.32	.26	.45	.34	.45	.37	.39	.42	.29	.35	.29	.77	.42	.45	.50	.32	.48	.55
15	.69	.70	.46	.32	.69	.54	.61	.39	.50	.56	.39	.30	.53	.42	.73	.64	.44	.36	.32	.60
16	.39	.70	.33	.24	.61	.45	.58	.27	.55	.42	.33	.30	.45	.45	.64	.90	.42	.30	.27	.61
17	.39	.50	.39	.31	.44	.36	.50	.42	.39	.47	.31	.28	.25	.50	.44	.42	.75	.39	.43	.47
18	.33	.27	.57	.63	.45	.47	.47	.63	.37	.33	.47	.22	.31	.32	.36	.30	.39	.79	.30	.47
19	.39	.45	.32	.25	.23	.34	.27	.25	.43	.34	.25	.30	.36	.48	.32	.27	.43	.30	.77	.36
20	.58	.70	.33	.33	.77	.37	.57	.37	.63	.28	.33	.30	.38	.55	.60	.61	.47	.47	.36	.79

For each cluster, the DRP with the highest average native overlap value to all other DRPs in the cluster was selected as the representative member to be used as the basis for phage display libraries (the calculation of native overlap is described in Methods). These average native overlap values for the representative DRPs are displayed along the matrix diagonal in bold. Additionally, pairwise structural alignments of all representatives were computed with SALIGN; the resulting native overlap values are displayed in off-diagonal cells in the matrix