Figure 3.

Effective interaction zones for each NTR and competition among multiple NTRs in the FG-Nups barrier of the native NPC. (A) The schematic represents the effective strong (darker color) and weak (lighter color) interaction zones between FG-domains (green clouds containing curved lines) and different NTRs including importins (Impß1, Impß2, and NTF2) and exportins (Crm1, CAS, and Tap-p15). Numbers denote nanometers. C, the cytoplasmic side of NPC; N, the nucleoplasmic side of NPC. (B) This figure is the representation of light (left) and heavy (right) competition among NTRs. Specifically, NTRs could find more available binding sites in the FG-Nups barrier (green clouds containing curved lines) under light competition conditions than heavy competition circumstances.