Fig. 6.
Sex differences in PVN neuron responses to slow pressor AngII. Fourteen days following slow pressor Angiotensin II delivered through osmotic minipumps, blood pressor increases in young males and in accelerated ovarian failure females from a timepoint that corresponds to “postmenopause” in humans. The trafficking of GluN1 and p47phox within PVN neurons varies depending on sex, ovarian hormone status and cell type. Arrows indicate direction of movement towards the plasma membrane. Receptors on the plasma membrane are available for ligand binding. Thus, an increase of GluN1 would indicate potential for greater excitability.