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. Author manuscript; available in PMC: 2017 Apr 10.
Published in final edited form as: Nat Genet. 2016 Oct 10;48(11):1418–1424. doi: 10.1038/ng.3680

Figure 2.

Figure 2

Bioinformatic functional interaction network analysis of proteins encoded by all positional candidate genes at all confirmed and suggestive vitiligo candidate loci. As a first step, unsupervised functional interaction network analysis was carried out using STRING v10.011, considering each protein as a node and permitting ≤ 5 second-order interactions to maximize connectivity. Nodes that shared no edges with other nodes were then excluded from the network. Edge colors are per STRING: teal, interactions from curated databases; purple, experimentally determined interactions; green, gene neighborhood; blue, databases; red, gene fusions; dark blue, gene co-occurrence; pale green, text-mining; black, co-expression; lavender, protein homology. Note that SMEK2 is an alternative name for PPP4R3B.