. 2016 Nov 23;11(11):e0167049. doi: 10.1371/journal.pone.0167049

Table 1. Effect of MO treatments on severity of histopathologic lesions in DOX-treated rats.

Groups	Disorganization	Focal necrosis	Degeneration	Inflammation
Control	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
DOX	3.00 ± 0.00^a	1.83 ± 0.17^a	2.17 ± 0.31^a	2.00 ± 0.26^a
DOX+MO(LD)	1.33 ± 0.21^a	0.67 ± 0.21^a	0.67 ± 0.21^a	1.00 ± 0.36^a
DOX+MO(MD)	1.00 ± 0.00^a	0.33 ± 0.21^a	0.33 ± 0.21^a	0.67 ± 0.21^a
DOX+MO(HD)	0.50 ± 0.22^a	0.17 ± 0.17^a	0.00 ± 0.00^a	0.50 ± 0.22^a

Severity of injury is expressed as mean ± SEM of three scores for seven animals in each group. a P<0.001 vs. DOX group. Grade 1 = 1: 10% mild. Grade 2 = 10–30% moderate. Grade 3 > 30% severe,

^a P<0.001 vs. control.