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. 2016 Nov 23;11(11):e0167073. doi: 10.1371/journal.pone.0167073

Fig 2. P-Smad3 is activated in proliferating cells.

Fig 2

Top: The co-localization of P-Smad3 and proliferating cell nuclear antigen (PCNA) indicates that Smad3 is activated in proliferating cells. Bottom: P-Smad3-positive cells in the inner nuclear layer (INL) co-localized with glutamine synthetase (GS), suggesting that these cells are Müller glia. Representative immunohistochemical staining at day 3 is depicted. Cell nuclei are stained with DAPI (blue). The scale bar indicates 25 μm. GC: ganglion cells, ONL: outer nuclear layer.