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. Author manuscript; available in PMC: 2017 Oct 24.
Published in final edited form as: Curr Biol. 2016 Oct 24;26(20):R1073–R1087. doi: 10.1016/j.cub.2016.08.068

Figure 2. Conserved neurotransmitter systems that control sleep.

Figure 2

Colored circles represent pharmacological, histological or genetic confirmation of the existence of neurotransmitter systems in mice, zebrafish and flies. The invertebrate neurotransmitter equivalent of norepinephrine is octopamine. Question marks label neurotransmitter systems that have not yet been tested for roles in regulating sleep in zebrafish. X indicates that in flies the single known adenosine receptor does not regulate sleep, though it does not exclude the possible involvement of additional adenosine receptors that have yet to be identified.