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The thermal antinociceptive effect of the lowest effective dose of pentazocine is mediated by KOR or MOR in OVX+E rats. The significant increase in TFL by 250 nmol pentazocine in OVX+E rats was blocked by either nor-BNI or CTAP pretreatment. Dotted lines indicate replotted data from Fig. 1 for clarity. Number of animals per group: pentazocine=12, pentazocine+CTAP=3, pentazocine+nor-BNI=5.
