Table 2.

Results of label-free quantitation of proteins significantly over-represented in desminopathy aggregate samples.

Acc.	Protein	SC	Pep. a	Aggregate (SI)	Control (SI)	Ratio	p-Value
P17661	Desmin	73.2	27	238.5	47.7	5.0	0.03
Q14315	Filamin C	43.2	89	93.9	30.6	3.1	0.01
A4UGR9	Xin actin-binding repeat-containing protein 2 (Xirp2)	28.0	4	82.7	0.0	n.a.	0.004
P02511	αB-Crystallin	57.7	9	65.9	6.3	10.4	0.03
Q86VF7	Nebulin-related-anchoring protein (N-RAP)	34.9	65	44.6	0.8	56.5	0.001
Q702N8	Xin actin-binding repeat-containing protein 1 (Xin)	15.5	29	16.3	0.2	72.8	0.003
P04792	Heat shock protein beta-1 (Hsp27/HspB1)	50.2	10	16.1	0.9	18.6	0.045
P08670	Vimentin	21.9	6	8.3	1.7	4.7	0.02
P33176	Kinesin-1 heavy chain	0.2	2	4.0	0.6	6.8	0.046
Q13642	Four and a half LIM domains protein 1 (FHL1)	11.8	4	3.1	1.6	1.9	0.045
P08123	Collagen α-2(I) chain	3.1	3	3.1	1.2	2.6	0.04
P28070	Proteasome subunit beta type-4	2.8	7	3.0	0.0	n.a.	0.03
Q15773	Myeloid leukemia factor 2	8.1	2	2.7	0.6	4.6	0.01
Q2TBA0	Sarcosynapsin	6.0	5	1.7	0.2	9.8	0.04
P13611	Versican core protein precursor	0.1	2	1.4	0.0	n.a.	0.007
Q7Z4W1	l-Xylulose reductase	16.0	4	1.4	0.0	n.a.	0.04
P07437	Tubulin beta chain	17.1	2	1.2	0.0	n.a.	2.3 × 10−5
Q86TC9	Myopalladin	3.6	5	1.2	0.0	n.a.	0.03
O95425	Supervillin	2.6	4	1.2	0.2	6.1	0.04
P16989	Cold shock domain-containing protein A (CSDA)	13.7	2	1.0	0.0	n.a.	0.01
O75955	Flotillin-1	7.0	2	0.8	0.0	n.a.	0.048
Q13535	FRAP-related protein 1	0.8	3	0.6	0.0	n.a.	0.047

Acc. = UniProtKB accession number, SC = sequence coverage (%), SI = spectral index, n.a. = not applicable.

^aNumber of different peptides.