Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Oct 26;5:e18295. doi: 10.7554/eLife.18295

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016, Dey et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

PMC Copyright notice

Figure 8. — Models depicting similarities in the development of HSCs from the mammalian AGM (A) and D. melanogaster’s cardiogenic mesoderm (B; redrawn from (Mandal et al., 2004). The cardiogenic mesoderm in Drosophila is analogous to the developing AGM of vertebrate and is nourished by identical signals. In vertebrates, a subset of AGM-derived cells has been proposed to constitute hemangioblasts (HB), which produce HSCs and endothelial cells. These HSCs also require BMP4 signaling from the AGM mesenchyme (AGM MC) for its maintenance. Likewise in flies, a seeding HB has been proposed to give rise to a subpopulation of cardioblasts and lymph gland primordia. Lymph gland progenitors are thus derived from few HSCs that also require niche-derived Dpp signaling for their maintenance. AGM: Aorta-Gonad-Mesonephros; EN: Endothelium; HSC: hematopoietic stem cell; FGF: Fibroblast Growth Factor; Heartless: FGF fly homolog Htl; AGM MC: AGM mesenchyme; FGF: fibroblast growth factor; BMP: Bone morphogen protein; Dpp: Decapentapelagic (BMP fly homolog); HB: Hemangioblast; PSC: Posterior Signaling Centre (Niche); DV: Dorsal vessel, heart.