Fig. 7.

Antigen-specific CD4 and CD8 memory T-cell profiles measured in PBMCs. Plots A and C, show representative bivariate density plots showing central to effector memory T-cell populations, defined by patterns of CD28 and CCR7 staining on CD95 expressing CD4 (A) and CD8 (C) T-cells, overlaid with cytokine producing cells represented as dots. Plot B displays the frequency of antigen-specific cytokine producing memory CD4 T-cell populations during the vaccination and M.tb infection phase of the study. Box plots show interquartile range with medians indicated. Plot C displays the frequency of antigen-specific cytokine producing memory CD8 T-cell populations during the vaccination and M.tb infection phase of the study. Box plots show interquartile range with medians indicated.