Fig. 8.

Relationship between PPD-specific IFN-γ SFU measured by ELISpot and frequency of antigen-specific CD4 TransEM populations. Correlation plots comparing the PPD-specific SFU measured by ELISpot and frequency of antigen-specific CD4 Transitional effector T-cell populations at six (A), 12 (B), 23 (C) and 25 (D) weeks following primary BCG vaccination. Note that week 23 and 25 also correspond to weeks two and four following aerosol M. tuberculosis infection, respectively (C and D). Data points represent individual animals. Spearman's correlation coefficient (r) and significance values (p) are indicated. A linear regression line is included for reference.