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. Author manuscript; available in PMC: 2017 Apr 24.
Published in final edited form as: Lab Invest. 2016 Oct 24;96(12):1256–1267. doi: 10.1038/labinvest.2016.112

Figure 9.

Figure 9

Determination of hHSC fibrotic reaction, in vitro. hHSCs treated with supernatants extracted from cholangiocytes isolated from BDL WT mice show increased FN-1, and Collagen-1a expression when compared to hHSCs treated with supernatants from Sham WT mice (A, B); however, these parameters were decreased in hHSCs treated with cholangiocyte supernatants from BDL miR-21−/− mice when compared to BDL WT mice (A, B). Data are expressed as means ± SEM. n = 6 reactions from 12 sets of cells for qPCR. *p<0.05 versus hHSCs + WT cholangiocyte supernatants; #p<0.05 versus hHSCs + BDL WT cholangiocyte supernatants.