Table 2. Summary of Roles for CRF1 and CRF2 in Preclinical Models of Neuropsychiatric Disorders.

Disorder	Depressive Disorders	Trauma and Stress-Related Disorders	Substance Related & Addictive Disorders	Anxiety Disorders
Preclinical Models	Forced swim test	Predator stress, Chronic unpredictable stress, Foot-shock stress	Stress-induced drug seeking. Binge-like ethanol intake. Withdrawal.	Elevated plus maze. Light-dark box, open field, novel object.
CRF1	↑ [42, 45]	↑ [25, 26, 54]	↑ [24, 60, 63, 67]	↑ [20]
CRF2	↓ [42]	↓ [25]	↓ [63, 67] ↑ [61]	↓ [11] ↑ [7, 9]

^↑= Data indicate that receptor stimulation promotes symptoms.

^↓=Data indicate that receptor stimulation decreases symptoms.