Table 1.
Cognitive Domains Affected in D2R-OE Mice and Patients With Schizophrenia
| Cognitive Domain | Test(s) applied in Humans | Outcome in patients with Schizophrenia (references) | Test applied in mice | Outcome in D2R-OE mice (reference) |
|---|---|---|---|---|
| Conditional Associative Learning | Visual conditional associative learning tests | Deficit in learning the task (32) and (33) | Auditory conditional associative learning tests | Deficit in learning the task. (31) |
| Inhibitory control | Visual Go/NoGo learning task | Reduced Response accuracy due to omitted Go trials (34) | Auditory Go/NoGo Task | Reduced response accuracy due to interference from prior trial (31) |
| Reversal Learning | Visual discrimination task | Deficit in simple discrimination and reversal trials (35) | Odor/texture discrimination task | Deficit in reversal trials-(36) |
| Time perception | Auditory temporal bisection procedure | Decreased temporal precision (37) | Auditory temporal bisection procedure | Decreased temporal precision (38; 39) |
| Time production | Self-paced time production task | Decreased temporal precision (40) | Peak Interval timing procedure | Decreased temporal precision (20) |
| Spatial Working Memory | oculomotor and haptic delayed-response tasks | Deficits in performance at 2 time delays. (41) | Non match to sample T-maze task | Deficit in acquisition (18) |
| Maintenance of information in Working memory | A visual, color based retention task. | Normal-(30) | Two choice visual discrimination task | Normal (42) |
| Problem Solving/Executive Function | Spatial mazes (Selected by MATRICS) | Poor performance (43) | Puzzle Box digging task | Impaired problem solving (44) |