Table 2.
Tissue volumes and comparisons: four groups. Tissue volumes and Analysis of Covariance (ANCOVA) results for the four subject groups (both MS patients and controls, young and old). Values reported as mean (SD). All p-values are uncorrected for multiple comparisons. Daggers denote values that survive Bonferroni correction for comparison with multiple groups (†) or regions of interest (‡).
| Younger control | Younger MS | Older control | Older MS | p (yC/yMS) | p (yC/oC) | p (yC/oMS) | p (yMS/oC) | p (yMS/oMS) | p (oC/oMS) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Global level | ||||||||||
| White | 732,105.8 (31,001.2) | 712,226.7 (49,240.6) | 732,776.1 (33,148.3) | 712,422.9 (38,048.7) | 0.16 | 0.95 | 0.14 | 0.17 | 0.92 | 0.15 |
| Grey | 831,717.9 (39,916.0) | 782,947.7 (47,128.5) | 784,524.5 (47,578.4) | 736,858.7 (44,119.2) | < 0.001†‡ | < 0.001†‡ | < 0.001†‡ | 0.72 | 0.003†‡ | 0.001†‡ |
| cGM | 656,787.4 (32,131.5) | 632,263.7 (39,229.3) | 621,226.4 (38,781.6) | 596,443.2 (40,896.4) | 0.011†‡ | 0.001†‡ | < 0.001†‡ | 0.60 | 0.007†‡ | 0.028 |
| scGM | 174,930.6 (11,659.8) | 152,175.8 (10,721.2) | 163,298.2 (11,037.0) | 141,774.5 (8627.0) | < 0.001†‡ | < 0.001†‡ | < 0.001†‡ | 0.006†‡ | 0.003†‡ | < 0.001†‡ |
| Regional level | ||||||||||
| Puta | 13,658.9 (1312.6) | 11,727.6 (1971.7) | 12,850.3 (1106.1) | 11,530.9 (1437.0) | < 0.001†‡ | 0.06 | < 0.001†‡ | 0.25 | 0.68 | 0.009 |
| Caud | 9888.8 (965.2) | 8647.7 (842.7) | 9352.6 (830.6) | 8556.9 (973.3) | < 0.001†‡ | 0.04 | < 0.001†‡ | 0.03 | 0.75 | 0.012 |
| Thal | 21,405.1 (1292.5) | 18,573.1 (1873.0) | 19,924.1 (1609.5) | 18,246.5 (1629.5) | < 0.001†‡ | 0.001†‡ | < 0.001†‡ | 0.002†‡ | 0.69 | 0.001†‡ |
| Hipp | 10,598.2 (1131.5) | 9452.6 (1438.6) | 9807.3 (926.0) | 9579.6 (953.0) | < 0.001†‡ | 0.014 | 0.001†‡ | 0.11 | 0.55 | 0.33 |
| Amyg | 3271.4 (543.1) | 2878.9 (411.8) | 3156.5 (619.9) | 2835.4 (525.1) | 0.026 | 0.45 | 0.012 | 0.15 | 0.77 | 0.09 |
| Accu | 1439.3 (199.7) | 1104.1 (266.9) | 1284.6 (191.2) | 1088.2 (215.7) | < 0.001†‡ | 0.014 | < 0.001†‡ | 0.005†‡ | 0.94 | 0.005†‡ |
| Pall | 4740.7 (430.7) | 4343.2 (584.7) | 4679.7 (587.4) | 4686.0 (1237.3) | 0.03 | 0.76 | 0.65 | 0.08 | 0.11 | 0.87 |