Table 1.

Description of imported ZIKV infection cases in the Netherlands, November 2015–February 2016 (n = 18)

Sex/age (years)	Country of birth	Date of symptom onset	Date of laboratory confirmation	Laboratory results CHIKV and DENV	Country of acquisition	Travel purpose	Symptoms	Complications	Blood abnormalities	Time to resolution (days)
M/61	SU	9 Dec 2015	11 Dec 2015	Not tested	SU	VFR/holiday	Itching rash, muscle ache, arthralgia	No	Leucopenia, atypical lymphocytes	2
F/54	SU	23 Dec 2015	30 Dec 2015	CHIKV neg DENV not tested	SU	VFR	Fever, itching rash, headache, oedema	No	Elevated liver enzymes; ASAT 32 U/L, LDH 257 U/L	>14
F/31	SU	21 Jan 2016	23 Jan 2016	CHIKV neg DENV IgG pos, IgM neg, NS1 ag test neg	SU	VFR/holiday	Rash, headache, arthralgia	No	Elevated liver enzymes; γ-GT 39 U/L	7
F/60	SU	8 Jan 2016	14 Jan 2016	CHIKV neg DENV IgG pos, IgM neg, NS1 ag test neg	SU	VFR/holiday	Fever, arthralgia	Yes, GBS	Elevated liver enzymes; AF 128 U/L, ALAT 69 U/L, ASAT 89 U/L, LDH 366 U/L	Unknown
F/33	NL	9 Jan 2016	11 Jan 2016	CHIKV qRT-PCR neg, serology pending, DENV IgG borderline, IgM neg, NS1 ag test neg	SU	VFR	Fever, itching rash, conjunctivitis, headache, muscle ache, arthralgia	No	Leucopenia	10
F/46	NL	5 Dec 2015	9 Dec 2015	CHIKV IgG/IgM neg, DENV NS1 ag test neg	SU	Holiday	Itching rash, conjunctivitis, headache, arthralgia, oedema	No	Yes, lymphopenia, atypical lymphocytes, elevated liver enzymes: LDH 297 U/L	28
M/47	NL	8 Dec 2015	17 Dec 2015	CHIKV IgG/IgM neg, DENV IgG pos, IgM weak pos, NS1 ag test neg	SU	Work	Fever, itching rash, conjunctivitis, arthralgia, muscle ache	No	Yes, atypical lymphocytes	21
F/53	NL	27 Dec 2015	30 Dec 2015	CHIKV n.a., DENV NS1 ag test neg	SU	Holiday	Fever, rash, conjunctivitis, headache, muscle ache, oedema	No	Yes, leucopenia, lymphopenia	14
M/8	NL	3 Feb 2016	4 Feb 2016	CHIKV n.a., DENV IgG/IgM neg, NS1 ag test neg	DO	VFR/holiday	Fever, rash, headache	No	Yes, leucopenia	10
F/61	NL	27 Nov 2015	1 Dec 2015	CHIKV IgG/IgM neg, DENV IgG neg, IgM weak pos, NS1 ag test neg	SU	Holiday	Itching rash, conjunctivitis, arthralgia	No	Yes, atypical lymphocytes	28
F/54	SU	17 Jan 2016	19 Jan 2016	CHIKV IgG/IgM neg DENV IgG neg, IgM weak pos, NS1 ag test neg	SU	Holiday	Fever, itching rash, conjunctivitis, arthralgia, oedema	Yes, thrombocytopenia	Yes, leucopenia, lymphopenia, atypical lymphocytes	28
F/56	SU	24 Dec 2015	30 Dec 2015	CHIKV n.a., DENV n.a.	SU	Holiday	Fever, rash, arthralgia, muscle ache, oedema	No	Yes, atypical lymphocytes	56
M/59	Unknown	24 Dec 2015	30 Dec 2015	CHIKV n.a., DENV n.a.	SU	Holiday	Fever, itching rash, conjunctivitis	No	Atypical lymphocytes	7
F/61	Unknown	4 Feb 2016	10 Feb 2016	CHIKV IgG/IgM neg, DENV IgG/IgM neg, NS1 ag test neg	SU	Holiday	Fever, rash, conjunctivitis, arthralgia	No	Lymphopenia	Unknown
F/60	NL	28 Nov 2015	2 Dec 2015	CHIKV IgG/IgM neg, DENV IgG/IgM neg, NS1 ag test neg	SU	Holiday	Fever, itching rash, arthralgia, muscle ache, oedema	No	Elevated liver enzymes: LDH 297 U/L	14
M/54	Unknown	2 Dec 2015	10 Dec 2015	CHIKV IgG/IgM neg, DENV IgG/IgM neg, NS1 ag test neg	SU	VFR	Fever, rash, arthralgia, muscle ache	No	Leucopenia, lymphopenia, atypical lymphocytes	14
M/40	NL	1 March 2016	3 March 2016	Not tested	SU	VFR/holiday	Fever, itching rash, muscle ache	No	Not measured	7
F/40	NL	1 March 2016	3 March 2016	CHIKV IgG/IgM neg, DENV IgG/IgM neg, NS1 ag test neg	SU	VFR/holiday	Fever, itching rash, muscle ache, arthralgia, oedema	No	Leucopenia, atypical lymphocytes	Unknown

M male, F female, CHIKV Chikungunya virus, DENV Dengue virus, SU Surinam, NL the Netherlands, DO Dominican Republic, NS1 ag test nonstructural protein 1 antigen test, neg negative, pos positive, qRT-PCR quantitative real-time polymerase chain reaction, VFR visiting friends and relatives, GBS, Guillain–Barré syndrome, ASAT aspartate amino transferase, LDH lactate dehydrogenase, γ-GT gamma-glutamyl transpeptidase, AF alkaline phosphatase, ALAT alanine aminotransferase, U/L units per litre