Figure 2.

Cannabidiol reduces the expression of auditory and contextual fear memory in rats. (A) Schematic representation of the experimental procedures used; the arrow indicates that drug was injected 30 min before extinction. (B) Freezing during tone-shock pairings did not differ between the groups during auditory fear conditioning. (C) Rats treated with 20 mg/kg of cannabidiol showed significantly decreased freezing during tone presentations at the start of extinction, compared to rats given 5 mg/kg or vehicle (^*P <0.05). (D) There were no differences in tone-induced freezing between the groups during extinction recall. (E) Rats treated with 5, 10, or 20 mg/kg of cannabidiol showed significantly decreased freezing in the 2 min period before tone presentations during extinction, compared to vehicle-treated controls (^**P <0.01). (F) There were no differences in freezing between the groups in the 2 min period before tone presentations during extinction recall (see Supplementary Material for more details).