Table 2.
Summary of central CBD effects on contextual fear memory processing in male rats (5-HT1AR, serotonin1A receptor; BNST, bed nucleus of the stria terminalis; CB1R, cannabinoid type1 receptor; i.c.v., intracerebroventricular; IL, infralimbic; i.p., intraperitoneal; PL, prelimbic).
| Strain | Dosing and site details | Effect | Possible mechanism | References |
|---|---|---|---|---|
| Wistar | 6.4 nmol, i.c.v., pre-retrieval | Facilitated fear extinction | Indirect CB1R activation | Bitencourt et al., 2008 |
| Wistar | 30 nmol, PL, pre-retrieval | Anxiolytic (↓ fear expression) | Not tested | Lemos et al., 2010 |
| Wistar | 30 nmol, IL, pre-retrieval | Anxiogenic (↑ fear expression) | Not tested | Lemos et al., 2010 |
| Wistar | 30–60 nmol, BNST, pre-retrieval | Anxiolytic (↓ fear expression) | 5-HT1AR activation | Gomes et al., 2012 |
| Long evans | 1.3 nmol, IL, pre-extinction | Facilitated fear extinction | Indirect CB1R activation | Do Monte et al., 2013 |
| Wistar | 30 nmol, PL, pre-retrieval | Anxiolytic (↓ fear expression) | 5-HT1AR activation | Fogaça et al., 2014 |
| Wistar | 30 nmol, IL, pre-retrieval | Anxiogenic (↑ fear expression) | 5-HT1AR activation | Marinho et al., 2015 |