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Effect of gene deletion or pharmacological inhibition of NPC1 against HPBCD cytotoxicity.
Cell viability was measured 3 h after HPBCD treatment using the WST-8 assay (A and C) and calcein-AM and PI co-staining (B and D). HPBCD-induced cytotoxicity in wild-type or Npc1 null CHO cells (A and B) and U18666A (1 μM) pretreated CHO cells (C and D). Values are the mean ± S.E.M., (n = 3–4). ** P < 0.01; * P < 0.05. Scale bar = 100 μm.
