TABLE 1.
Summary of 7H9 broth microdilution MIC QC ranges against M. tuberculosis H37Rv strain for anti-TB drugs
| Drug | Dilution range used in the study (μg/ml) | MIC QC range (μg/ml) |
|---|---|---|
| First-line drugs | ||
| Isoniazida | 0.03–1 | 0.03–0.12 |
| Rifampin | 0.06–1 | 0.03–0.25 |
| Ethambutol | 0.25–8 | 0.25–2 |
| Nicotinamideb | 16–512 | NAe |
| Fluoroquinolones | ||
| Levofloxacin | 0.12–4 | 0.12–1 |
| Moxifloxacin | 0.06–2 | 0.06–0.5 |
| Ofloxacin | 0.12–4 | 0.25–2 |
| Second-line injectables | ||
| Amikacin | 0.12–8 | 0.25–2 |
| Kanamycinc | 0.12–8 | 0.25–2 |
| Capreomycin | 0.12–4 | 0.5–4 |
| Oral bacteriostatic drugs | ||
| Prothionamide | 0.06–2 | NA |
| Ethionamide | 0.12–4 | NA |
| WHO category 5 drugs | ||
| Linezolid | 0.12–4 | 0.25–2 |
| Clofazimined | 0.06–1 | 0.03–0.25 |
a
QC range derived from microtiter plate Lot-1 and Lot-2 only.
b
Nicotinamide was included as a potential surrogate for pyrazinamide.
c
QC range derived from Lot-2 and Lot-3 only.
d
The modal concentration of clofazimine, 0.06 μg/ml, was the lowest concentration tested.
e
NA, not applicable as QC ranges that included at least 95% of the observed values could not be set.