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. 2016 Oct 17;5(10):e003910. doi: 10.1161/JAHA.116.003910

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© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Reduction of endogenous SO ₂ in PASMCs increased collagen accumulation in PAFs. A, Changes in the SO ₂/AAT1 system in PASMCs. B, Collagen accumulation in PAFs. Results are expressed as mean±SE for 3 separate experiments (n=3), each in triplicate. *P<0.05 compared with the vehicle group. AAT1 indicates aspartate aminotransferase 1; PAF, pulmonary arterial fibroblast; PASMC, pulmonary artery smooth muscle cell; SO₂, sulfur dioxide.